How your genes could reveal what you look like.
Male, short and stout, with dark skin, brown eyes, shovel-shaped teeth, type A+ blood and coarse, dark brown hair giving way to pattern baldness. He would have a high tolerance for alcohol and a higher-than-average risk of nicotine dependence—fortunately, he lived thousands of years before humans discovered smoking. The description of a Stone Age Greenland resident published in February paints an extraordinary portrait of a man who vanished more than 4,000 years ago, drawn almost solely from his DNA remains.
Male, short and stout, with dark skin, brown eyes, shovel-shaped teeth, type A+ blood and coarse, dark brown hair giving way to pattern baldness. He would have a high tolerance for alcohol and a higher-than-average risk of nicotine dependence—fortunately, he lived thousands of years before humans discovered smoking. The description of a Stone Age Greenland resident published in February paints an extraordinary portrait of a man who vanished more than 4,000 years ago, drawn almost solely from his DNA remains.
The analysis, led by Danish scientists, not only marks the first full sequencing of an ancient human genome but also offers a startling example of how much modern-day detectives can discern just from a suspect’s genetic code. Far beyond using DNA “fingerprints” to link an individual to a crime scene, forensic profiling is edging toward the capability to create a police-artist-style sketch of an unknown person by reading traits inscribed in the genome. “The body interprets the DNA to determine the appearance of the face,” says anthropologist Mark Shriver of
The scientists reconstructing the ancient Greenlander had only a few tufts of hair, preserved in permafrost, from which they extracted DNA. The hair itself is dark and thick and contains chemical traces indicating mainly a seafood diet. From the man’s genes, the researchers resolved a long-standing debate about the origins of
Together those traits might not make the ancient Greenlander stand out in a lineup, but they could dramatically narrow the search for suspects. A handful of high-profile criminal cases has already demonstrated the utility of even basic prospective information. In 2007 Christopher Phillips and his colleagues at the
Having more to go on than ancestry, a generally poor indicator of appearance, is the goal of programs such as the DNA Initiative of the National Institute of Justice, which funds research into alternative genetic markers for forensic use. Daniele Podini of
Getting more specific gets significantly more difficult, Podini adds. DNA alone offers few clues to age, for instance. With whole cells, researchers could examine telomeres, the chromosomal end caps that wear away with time, but individual health and other factors can influence their shrinkage. One recent study showed that dedicated athletes in their 50s might have the telomeres of a 25-year-old. Another important feature in profiling, height, has hereditary roots but also depends on environmental factors, such as nutrition during childhood.
Nevertheless, pinning down the effects of genes that influence body development is the key to predicting a specific individual’s looks. Shriver is studying populations in
Skin-deep is as far as a DNA sketch should go, according to some bioethicists. The ancient Greenlander also had an elevated risk for hypertension and diabetes. A modern all-points bulletin could, in principle, describe a suspect’s pigmentation, ancestry, and higher-than-average likelihood of being obese, a smoker, alcoholic or just depressed. “I think there are some valid ethical issues around this kind of work,” Shriver remarks.
Practical considerations may be what delays deployment of any but the simplest forensic kits, though. “The forensic field is very, very conservative,” Podini says, “so before you actually apply something to casework, it has to be proven beyond a reasonable doubt as something that works well, is reliable and is accepted by the scientific community.”